Northern,WI  1/28/2013 (BasicsMedia) – As the morning settles into the afternoon we now start to look at the other side of the coin and see who is taking it on the chin early in the week.

      Our first downward mover is Repros Therapeutics Inc. (RPRX) which is off some 30% in morning trading. Repros recently provided an update on its phase III program for Androxal. The candidate is being evaluated for the treatment of secondary hypogonadism.

The company announced that it has completed the enrollment process for the one-year study, DEXA (ZA-303), evaluating the effects of Androxal on bone mineral density. The company completed the enrollment three months before the scheduled date. The company expects to file a New Drug Application (:NDA) for Androxal primarily on the basis of data from the DEXA study by mid-2014.

The company plans to continue to enroll patients for study so that the safety requirement of minimum exposure of 800 patients for 6 months mandated by the US Food and Drug Administration (:FDA) is fulfilled.

Repros Therapeutics is also conducting a six-month open label study, ZA-300 (n~500), to build a safety database as required by the FDA. The company has recruited 415 patients and expects to complete recruitment by the end of the first quarter of 2013.

We note that the Androxal phase III program also includes two pivotal phase III studies, ZA-301 and ZA-302. While the ZA-301 study is currently underway, enrollment for the ZA-302 is expected to completed shortly.

You’ve seen the ads for our next company I’m sure and if your like me you wonder how they can give a suit or two for free if you buy one? Taking a 18% hit in value this morning we find Shares of Jos. A. Bank Clothiers Inc. (JOSB) dropping to their lowest point in more than two years as the men’s clothing company announced its fiscal 2012 net income will be about 20 percent lower than the previous year.

The retailer’s 2011 net income was $97.5 million, which implies $78 million for 2012.

Late  last Friday, Jos. A. Bank said that its full-year sales will be up, but will not offset increased marketing expenses and lower gross margin.

President and CEO R. Neal Black said in a statement that the Hampstead, Md.-based company’s fourth-quarter sales started out slow due to Superstorm Sandy, the distractions of the presidential election and uncertainty surrounding whether the government would go over the fiscal cliff at the start of the New Year.

Black said the retailer thought business would pick up during the holiday season, but that its results were hampered by unseasonably warm weather since many of its promotional items and holiday assortment was geared toward colder temperatures.

Our final slider for the day losing some 11% this morning is the 3D Systems Corp. (DDD). 3D has agreed to terms for a deal for to buy Coweb of Paris. Coweb is a startup company that creates customized three-dimensional printed collectibles and other products over the Internet. 3D Systems (NYSE:DDD) now plans to offer the customized figures on its online hosting and publishing platform, Cubify.

“Coweb’s creative approach to delivering unique products to a growing consumer audience matches up perfectly with the Cubify platform,” says Sarah Stocker, senior director of customer solutions business of 3D Systems.

The company produces machinery that makes three-dimensional prototypes and working parts for a range of industries, from plastics to auto racing.


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